AneVivo™ - An In vivo Natural Fertilisation

Anecova has developed a unique in-vivo fertilisation procedure that allows the complete fertilisation process to occur inside the women’s womb. This fertilisation method can be ideally combined with traditional IVF or with procedures requiring mild or no hormonal stimulation.

AneVivo™, our first product, restores fertilisation to the natural environment of the maternal womb using an In Vivo fertilisation procedure. This technology offers numerous benefits to both the mother and the embryos.

The mother benefits psychologically by playing an active role in the fertilisation of her embryos. It is expected that the presence of the embryos in the maternal environment will lead to the mother being better prepared for, and more receptive to, embryo implantation. The embryos benefit at the start of their life, during the fertilisation and early development, from optimal conditions within the maternal environment. This is expected to optimize the production of highly competent embryos.

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AneVivo™ Natural fertilisation is a more natural approach to fertility treatment

  • The mother plays an active role
  • Fertilization occurs in the woman’s body
  • Allows interaction between the mother and the embryo
  • Beneficial psychological impact
  • Potentially prepares the endometrium for implantation of the embryo

Treatments

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AneVivo™ Natural Fertilisation

A more natural procedure for the benefit of the embryo and the future mother.In combination with AneVivo™, patients can play an active role from the start. The porous capsule of the AneVivo’s medical device placed in the patient’s uterus, allows the embryo’s fertilisation and early development to occur “in vivo” with endometrial nutrients and factors, allowing potential crosstalk between the uterine cavity and the embryo.

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AneVivo™ for Egg Donation recipients

With AneVivo™ Natural Fertilisation procedure, Egg Donation patients, can play an active role in the fertilisation of the embryos. This is the first and one of the most important steps in the development of an embryo.

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AneVivo™ Natural Cycle

This combination not only allows the fertilisation and early development to happen in vivo without stimulation, but also to avoid freezing any embryos. The patient follows her own cycle and each month goes to the clinic for a pick up. After a small number of oocytes have been collected, the patient can have the AneVivo™ Natural Fertilisation procedure. This procedure could also be done with stimulation, managing transfers with no embryos freeze.

Procedure

Stage 1

The gametes, inseminated or injected eggs or zygotes are enclosed in the AneVivo™ device and placed in the maternal uterine cavity during fertilisation and / or the early development stages.

Stage 2

After the chosen development period the AneVivo™ device and embryos are retrieved from the uterine cavity. At this stage, depending on the specific treatment, the embryos may be cultured in vitro for a short period.

Stage 3

The embryos are assessed in the laboratory. An embryologist will select the best quality embryos and the required number will be transferred to the uterine cavity using the traditional embryo transfer procedure with the objective of implantation.

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Benefits

Crosstalk

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It is expected that the presence of the embryos in the maternal environment will lead to the mother being better prepared for, and more receptive to, embryo implantation.

More natural

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The embryos benefit at the start of their life, during the fertilisation and early development, from optimal conditions within the maternal environment. This is expected to optimize the production of highly competent embryos.

Participate

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The mother benefits psychologically by playing an active role in the fertilisation of her embryos. Mother benefits psychologically by playing an active role in the fertilisation.

Potential Clinical benefits of the Natural Fertilisation approach are numerous

In vivo, the impregnated eggs bathe in a physiological, dynamic environment and naturally experience all the optimized biophysical conditions and the full range of the molecules needed for optimal embryo fertilisation & development and for optimal regulation of the development (genetic, gene expression regulation, epigenetic, imprinting).

In vivo, the impregnated eggs develop in an environment enabling the transmission of the parental epigenetic environment to the offspring, as it is the case in the natural conception (transgenerational epigenetic inheritance).

The uterine cavity responds and adapts to the presence of the embryos by optimally preparing for the embryo implantation process, as is similarly seen in natural conception. This response is mediated and finely controlled by molecules that are specific of the natural fluids (i.e. cytokines, growth factors, miRNA).

The Anecova’s approach expected to open new perspectives in the related domain of ART and to resolve possible effects arising from the in vitro culture condition limitations.

Physiological Environment

The culture environment in which the very first stages of embryo development take place is critical.

For in vitro techniques the culture media remains artificial, static and often omits a large number of components that are naturally present in the uterine cavity. More importantly, the laboratory context misses all the biological interactions between the developing embryos and the maternal environment.

To date, there are a growing number of studies in Humans investigating the possible impact of culture conditions on embryo development and on various observed adverse perinatal outcomes

  • Homeostasis
  • Architecture of the mitotic spindle
  • Birth weight
  • Vascular function
  • Diabetes
  • Epigenetic control of the gene expression

Although there are some controversies and possible confounding factors; several published data show that some developmental issues and adverse outcomes occur more frequently after ART than with natural conception.

By minimizing the impact of artificial culture conditions (e.g., synthetic culture media) on the development of the embryo, the risk of alteration of the embryo by exogenous factors or the absence of important molecules for the regulation of the embryo development should be dramatically reduced.

It is therefore paramount to try to replicate in the traditional laboratory of a fertility centre the physiological composition of the natural maternal environment.

Anecova’s innovative approach places injected or inseminated eggs in the maternal uterine cavity during fertilisation and very early development stages, so that the embryo can benefit from the mother’s natural, physiological environment.

Restoring fertilisation and early development of the embryos to the maternal womb is expected to optimize the production of highly competent embryos. The embryos can benefit from the full range of nutrients and active substances in the maternal environment as well as signals from the mother.

This natural incubation procedure enables the future parents to play a more active role at the very beginning of fertility treatment. It allows a stronger emotional involvement in these early stages whilst the maternal environment responds to the presence of the embryos and is prepared for embryo implantation.

European Clinical Partners

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Find a clinic

Anecova is working with partners that are leaders in their field, open to innovation, sensitive about the importance of more natural approaches to Assisted Reproduction Technologies (ART), with outstanding teamwork, performance and clinical management.
Our aim is to make the AneVivo based Natural Fertilization more widely available through building strong relationships within the clinics over time.

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